A structural model of genome-wide association studies

05/20/2022
by   Christopher Salahub, et al.
0

A structural genetic model incorporating a modern understanding of the genome and common practice in genome-wide association studies is derived mathematically. The model shows the Haldane map distance as a direct consequence of the structure of the genome. An expression for genetic correlation is derived under the model and compared to data resulting from the BSB mouse cross. A correlation test plot is introduced for this comparison and shows the close agreement of the model and empirical results. Noteworthy departures in this plot indicate regions which warrant further investigation.

READ FULL TEXT

Please sign up or login with your details

Forgot password? Click here to reset