On the Hill relation and the mean reaction time for metastable processes
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We illustrate how the Hill relation and the notion of quasi-stationary distribution can be used to analyse the error introduced by many algorithms that have been proposed in the literature, in particular in molecular dynamics, to compute mean reaction times between metastable states for Markov processes. The theoretical findings are illustrated on various examples demonstrating the sharpness of the error analysis as well as the applicability of our study to elliptic diffusions.
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