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02/19/2023
Design and Sample Size Determination for Multiple-dose Randomized Phase II Trials for Dose Optimization
The conventional more-is-better dose selection paradigm, which targets t...
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02/25/2022
On singular values of large dimensional lag-tau sample autocorrelation matrices
We study the limiting behavior of singular values of a lag-τ sample auto...
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10/01/2018
TOP: Time-to-Event Bayesian Optimal Phase II Trial Design for Cancer Immunotherapy
Immunotherapies have revolutionized cancer treatment. Unlike chemotherap...
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07/23/2018
Time-to-Event Model-Assisted Designs to Accelerate Phase I Clinical Trials
Two useful strategies to speed up drug development are to increase the p...
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12/18/2017