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06/07/2023
Evaluating the impact of outcome delay on the efficiency of two-arm group-sequential trials
Adaptive designs(AD) are a broad class of trial designs that allow prepl...
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05/17/2023
Utilising high-dimensional data in randomised clinical trials: a review of methods and practice
Introduction Even in effectively conducted randomised trials, the prob...
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05/24/2022
Bayesian sample size determination in basket trials borrowing information between subsets
Basket trials are increasingly used for the simultaneous evaluation of a...
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12/18/2020
Multi-outcome trials with a generalised number of efficacious outcomes
Existing multi-outcome designs focus almost entirely on evaluating wheth...
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10/13/2020
Conditional Power and Friends: The Why and How of (Un)planned, Unblinded Sample Size Recalculations in Confirmatory Trials
Adapting the final sample size of a trial to the evidence accruing durin...
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07/08/2020
Two-stage single-arm trials are rarely reported adequately
Purpose: Two-stage single-arm trial designs are commonly used in phase I...
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06/28/2020
A review of Bayesian perspectives on sample size derivation for confirmatory trials
Sample size derivation is a crucial element of the planning phase of any...
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09/06/2019
Optimal curtailed designs for single arm phase II clinical trials
In single-arm phase II oncology trials, the most popular choice of desig...
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06/21/2019
A web application for the design of multi-arm clinical trials
Multi-arm designs provide an effective means of evaluating several treat...
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06/13/2019