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08/24/2023
A preplanned multi-stage platform trial for discovering multiple superior treatments with control of FWER and power
There is a growing interest in the implementation of platform trials, wh...
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05/24/2022
Bayesian sample size determination in basket trials borrowing information between subsets
Basket trials are increasingly used for the simultaneous evaluation of a...
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12/12/2021
A multi-arm multi-stage platform design that allows pre-planned addition of arms while still controlling the family-wise error
There is growing interest in platform trials that allow for adding of ne...
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07/26/2021
A Comparison of Various Aggregation Functions in Multi-Criteria Decision Analysis for Drug Benefit-Risk Assessment
Multi-criteria decision analysis (MCDA) is a quantitative approach to th...
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04/30/2021
A Comparison of Model-Free Phase I Dose Escalation Designs for Dual-Agent Combination Therapies
It is increasingly common for therapies in oncology to be given in combi...
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10/07/2020
A Seamless Phase I/II Platform Design with a Time-To-Event Efficacy Endpoint for Potential COVID-19 Therapies
In the search for effective treatments for COVID-19, initial emphasis ha...
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06/23/2020
Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs
Adaptive designs for clinical trials permit alterations to a study in re...
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07/16/2018
Improving Safety of the Continual Reassessment Method via a Modified Allocation Rule
This paper proposes a novel criterion for the allocation of patients in ...
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03/12/2018
An information-theoretic Phase I/II design for molecularly targeted agents that does not require an assumption of monotonicity
For many years Phase I and Phase II clinical trials were conducted separ...
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12/23/2017