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09/06/2022
The Cost of Sequential Adaptation
Possibility of early stopping or interim sample size re-estimation lead ...
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06/22/2022
Coping with Information Loss and the Use of Auxiliary Sources of Data: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions
Clinical trials disruption has always represented a non negligible part ...
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02/07/2022
Estimands and their Estimators for Clinical Trials Impacted by the COVID-19 Pandemic: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions
The COVID-19 pandemic continues to affect the conduct of clinical trials...
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01/27/2021
Most Powerful Test Sequences with Early Stopping Options
Sequential likelihood ratio testing is found to be most powerful in sequ...
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08/04/2019
Effect of Interim Adaptations in Group Sequential Designs
This manuscript investigates unconditional and conditional-on-stopping m...
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05/23/2019
Random Norming Aids Analysis of Non-linear Regression Models with Sequential Informative Dose Selection
A two-stage adaptive optimal design is an attractive option for increasi...
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12/10/2018
